Type 2 diabetes is associated with intestinal bacteria

Intestinal bacteria influence the incidence of type 2 diabetes. Scientists have found that the loss of one species of intestinal bacteria linked to the development of this disease, writes about this Science Translational Medicine.

In particular, researchers have linked type 2 diabetes with a decline in the population of intestinal bacteria Akkermansia machinefile (A. Muciniphila). They found that in old mice these bacteria are less than in young individuals. According to scientific experts, reducing the number of bacteria of a given species is correlated with increased inflammatory processes in the body that can contribute to the development of resistance of body cells to the hormone insulin. Such violation precedes the development of type 2 diabetes.

The authors of the study were specialists of the National Institute on ageing in Baltimore. They watched as the mouse as you age lost intestinal bacteria A. Muciniphila. The loss of intestinal bacteria led to the subsidence of the production of butyrate, an important nutrient of the intestinal microflora. In view of the consequences it caused a chain reaction of dysfunction of immune cells.

“These intestinal bacteria are friendly bacteria that help to break down dietary fiber into short chain fatty acids such as butyrate and acetate. Fatty acids are signaling bacteria and human cells to perform certain functions. The reduction in the number of intestinal bacteria causes inflammation that can lead to the fact that the cells start to ignore the signals of insulin,” – said the scientists.
Treatment of old mice with the antibiotic enrofloxacin, and also the addition of butyrate has helped to increase the level of bacteria Akk in the gut and cause the cells to again respond to insulin. Scientists believe that uspeshnaja of insulin resistance in humans is also possible.

Earlier Magicforum wrote that intestinal bacteria generally affect the aging process.